By Andrew Hadley, Peter Soothill
The potent prevention, prognosis, and administration of alloimmune cytopenias has develop into a group attempt concerning hematologists, obstetricians, pediatricians, immunologists, laboratory technicians, midwives, and study scientists. This e-book has been written through specialists of their respective fields to collect the problems of pathogenesis, epidemiology, prevention, analysis, and medical administration. This finished yet available account is widely cross-referenced to stress the hyperlinks among pathogenesis and scientific sequels, among epidemiology and the reason for screening courses, and among analysis and healing intervention.
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Extra resources for Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn
Although the D-positive/D-negative polymorphism is relatively straightforward, there are numerous complexities involving D antigen expression. In the weak D phenotype (previously called Du), all epitopes of D are expressed weakly and these individuals do not produce anti-D when transfused with red cells with normal D expression. 23 Partial D phenotypes are D-positive phenotypes in which a few or many epitopes of D are not expressed. This loss of epitopes may be due to amino acid substitutions in extracellular domains of the D protein or to the product of hybrid RHD genes, in which a segment of the gene is replaced by the homologous segment derived from RHCE.
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Human IgG subclasses in maternal and fetal serum. Vox Sanguinis, 21, 481–92. 34 Story CM, Mikulska JE & Simister NE (1994). A major histocompatibility complex class Ilike Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. Journal of Experimental Medicine, 180, 2377–81. 35 Kohler PF & Farr RS (1966). Elevation of cord over maternal IgG immunoglobulin: evidence for an active placental IgG transport. Nature, 210, 1070–1. 36 Hughes-Jones NC, Ivona M, Ellis J & Walker W (1971).