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Red blood cells and their precursors are eliminated from FC analysis by lysis. 10 presents examples of CD45 versus SSC in some neoplastic processes, to illustrate the properties mentioned above. 10A). Other B- and T-cell lymphoproliferative disorders usually have a similar location. 10B) have bright CD45, but SSC is higher than in lymphocytes. A similar distribution is often observed in hairy cell leukemia and T-LGL leukemia. 10C). Precursor B- and T-lymphoblastic leukemias, blastic NKcell lymphoma/leukemia (DC2 acute leukemia) and occasional B- and T-cell lymphomas have a similar location in the blastic gate.
Higher magnification (B) shows germinal center with one pole composed of larger lymphocytes with macrophages (polarization, arrow). The follicular dendritic cell meshwork is preserved (C, CD21 staining). Bcells are visualized by staining with CD20 (D). T-cells are restricted to the perifollicular area (E, CD3 staining). Germinal center cells do not coexpress Introduction 45 bcl-2, a useful parameter in distinguishing between follicular hyperplasia and follicular lymphoma (F) over the erythroid series (the ratio is roughly 2:1).
Intact (compact) distributions of follicular dendritic cell meshwork favors a reactive process, whereas an expanded or disrupted meshwork is seen in lymphomas, such as marginal zone lymphoma, follicular lymphoma or nodular lymphocyte-predominant Hodgkin lymphoma. The lymphoid cells between follicles (paracortex or interfollicular region) are composed predominantly of small Tcells with rare centroblasts (depending on the degree of activation), scattered interdigitating reticulum cells and the high endothelial venules.