By Richard O. Day, Daniel E. Furst, Piet L.C.M. van Riel, Barry Bresnihan
This publication supplies a finished evaluate of disease-modifying antirheumatic medicines (DMARDs). The introductory normal chapters take care of the chemistry of DMARDs, their use in treatment, pharmacoeconomics, and a survey of opinion leaders within the box; the next particular chapters symbolize every one agent in regards to mechanism of motion, treatment, pharmacology, efficacy, toxicity, and tracking. for every agent a few history is given, fresh advancements and impression of the remedy on sufferers` caliber of existence and long term results are offered.
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Extra resources for Antirheumatic Therapy: Actions and Outcomes (Progress in Inflammation Research)
Arthritis Rheum 46 (2): 347-356 22 Mottonen T, Hannonen P, Korpela M, Nissila M, Kautiainen H, IIonen] et al (2002) Delay to institution of therapy and induction of remission using single- drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis Rheum 46 (4): 894-898 23 Felson DT, Anderson Meenan RF (1990) The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis. Results of two metaanalyses. Arthritis Rheum 33 (10): 1449-1461 24 Felson DT, Anderson Il, Meenan RF (1992) Use of short-term efficacy/toxicity tradeoffs to select second-line drugs in rheumatoid arthritis.
Unfor- 34 Targeting DMARD therapy tunately, the best marker of response remains observation through trial and error. In general, for most patients, response to a DMARD occurs within the first months of therapy, and it is unlikely that a patient will respond favorably if there has been no benefit after a trial of a few months. Although not sufficiently predictive, some markers have been associated with the likelihood of response. Rheumatoid factor is not conclusively related to clinical response to DMARDs, but observational cohort studies, in which invariably all patients are treated, show that patients with positive RF have worse outcomes, especially radiological, which indirectly suggests that response to DMARDs is weaker in seropositive patients.
Free Rad Bioi Med 7: 659-673 Svartz N (1942) Salazopyrin, a new sulfanilamide prepara tion : a. therapeutic results in rheumatic polyarth ritis; b. therape utic results in ulcerative colitis; c. toxic manifestations in treatment with sulfanilamide prepa rations. Acta Med Scand 110: 577-598 Bondesen S, Nielsen OH, Schou JB, Jensen PH, Lassen LB, Binder V, Krasilnikoff PA, Dano P, Ha nsen SH, Jacobsen 0 et al (1986) Steady-state kinetics of 5-aminosalic ylic 23 GarryG. Graham acid and sulphapyridine during sulfasalazine prophylaxis in ulcerative colitis.