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By Denis Diderot

Édition de Myrtille Méricam-Bourdet et Catherine Volpilhac-Auger.

Dix-sept volumes, seventy two 000 articles, five 800 attribués à Diderot : dans cette entreprise specific que fut l'Encyclopédie, nous avons retenu a hundred articles rédigés par Diderot. Non pas toujours les plus connus, mais les plus représentatifs de son génie, qui consiste à répondre aux questions que parfois le lecteur ne se posait pas, et ainsi à éveiller les consciences. Ce choix reflète les différentes facettes de son activité : Diderot éditeur, qui corrige et complète les textes des collaborateurs de l'entreprise ; Diderot auteur, débordant d'enthousiasme quand le sujet le passionne, piquant l. a. curiosité du lecteur et l'entraînant sur des chemins nouveaux, en transformant les règles de l'écriture encyclopédique. Maniant aussi bien l'ironie que l. a. critique, il n'hésite pas à adopter un ton group of workers, en mettant en scène ses hésitations, ses interrogations, ses convictions. Une nouvelle manière de thinker est née.

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2À2 mM for hepatic ADH) but, contrasting with hepatic ADH, which is not inducible in primates as well as most other animal species, enhanced levels of both hepatic CYP2E1 protein and its mRNA were found in actively drinking patients. The presence of CYP2E1 was also shown in extrahepatic tissues and in nonparenchymal cells of the liver, including Kupffer, but not stellate, cells. In rats, ethanol treatment caused a sevenfold increase in CYP2E1 content of the Kupffer cells. Increased Xenobiotic Toxicity and Carcinogenicity; Oxidative Stress Much of the medical signi®cance of the MEOS (and its ethanol-inducible CYP2E1) results not only from the oxidation of ethanol but also from the unusual and unique capacity of CYP2E1 to generate reactive oxygen intermediates, such as superoxide radicals.

Colon cancers enhance following the administration of contrast. Similarly, peritumoral extension, lymph node metastases, and peritoneal seeding all enhance on fatsuppressed Gd T1-W SGE imaging (Fig. 4). Lymph node metastases are common with alimentary tract malignancies and may be present in ``nonpathologically'' enlarged nodes; their presence may be inferred, however, when noting greater than ®ve lymph nodes measuring 510 mm in short axis in a regional distribution related to the primary tumor.

Recurrent tumors tend to be more nodular and ``masslike'' compared to postradiation ®brosis; though the two entities may coexist. Following 1 year of treatment, radiation ®brosis is often low in signal intensity on both T1-W and T2-W sequences and has negligible enhancement (Fig. 5). Unfortunately, associated granulation tissue may also demonstrate high signal intensity for up to 3 years posttreatment. This phenomenon is most pronounced with patients who have received 445 mGy. Similarly, overlap in signal intensity between recurrent disease and ®brosis on T2-W SSFSE can occur when normal high-signal-intensity fat is admixed with low- signal-intensity ®brosis (Fig.

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